Omega-3 reduced anxiety and inflammation in healthy students

A recent study gauging the impact of consuming more fish oil showed a marked reduction both in inflammation and, surprisingly, anxiety among a group of healthy young people.

The research, supported by the Ohio State University Center for Clinical and Translational Science (CCTS), was conducted by a team of scientists that has spent more than three decades investigating links between psychological stress and immunity.

“The findings suggest that if young people can get improvements from dietary supplements then the elderly and people at high risk for certain diseases might benefit even more,” said Janice Kiecolt-Glaser, Professor of Psychiatry and author of the study, which was published in the journal Brain, Behavior and Immunity.

“The more we understand about the complex interplay between inflammation and immunity, the closer we’ll get to figuring out which lifestyle choices and changes have the biggest impact on long-term health,” said the professor.

Omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have long been considered as positive additives to the diet. Earlier research suggested that the compounds might play a role in reducing the level of cytokines in the body, compounds that promote inflammation.

Psychological stress has repeatedly been shown to increase cytokine production so the researchers wondered if increasing omega-3 might mitigate that process, reducing inflammation.

To test their theory, they turned to a familiar group of research subjects - medical students. Some of the earliest work these scientists did showed that stress from important medical school tests lowered students’ immune status.

“We hypothesised that giving some students omega-3 supplements would decrease their production of proinflammatory cytokines, compared to other students who only received a placebo,” explained Kiecolt-Glaser.

“We thought the omega-3 would reduce the stress-induced increase in cytokines that normally arose from nervousness over the tests,” she said.

The team assembled a field of 68 first- and second-year medical students who volunteered for the clinical trial. Half the students received omega-3 supplements while the other half were given placebo pills. The students were randomly divided into six groups, all of which were interviewed six times during the study. At each visit, blood samples were drawn from the students, who also completed a battery of psychological surveys intended to gauge their levels of stress, anxiety or depression. The students also completed questionnaires about their diets during the previous weeks.

“The omega-3 supplement the students received was probably about four or five times the amount of fish oil you’d get from a daily serving of salmon,” explained Martha Belury, Professor of Human Nutrition and co-author in the study.

Part of the study, however, didn’t go according to plan.

Changes in the medical curriculum and the distribution of major tests throughout the year, rather than during a tense three-day period as was done in the past, removed much of the stress that medical students had shown in past studies.

“These students were not anxious. They weren’t really stressed. They were actually sleeping well throughout this period, so we didn’t get the stress effect we had expected,” Kiecolt-Glaser said.

But the psychological surveys clearly showed an important change in anxiety among the students. Those receiving the omega-3 showed a 20% reduction in anxiety compared to the placebo group. An analysis of the blood samples from the medical students showed similar important results.

“We took measurements of the cytokines in the blood serum, as well as measured the productivity of cells that produced two important cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα),” said Ron Glaser, Professor of Molecular Virology, Immunology & Medical Genetics and Director of the Institute for Behavioral Medicine Research.

“We saw a 14% reduction in the amounts of IL-6 among the students receiving the omega-3.” Since the cytokines foster inflammation, “anything we can do to reduce cytokines is a big plus in dealing with the overall health of people at risk for many diseases”, he said.

Inflammation is a natural immune response that helps the body heal, but it also can play a harmful role in a host of diseases ranging from arthritis to heart disease to cancer.

Even though the study showed omega-3 supplements can reduce both anxiety and inflammation - and some of the researchers said that they take omega-3 supplements - the researchers aren’t ready to recommend that the public start taking them daily.

“It may be too early to recommend a broad use of omega-3 supplements, especially considering the cost and the limited supplies of fish needed to supply the oil,” Belury said. “People should just consider increasing their omega-3 through their diet.”

Also working on the research with Kiecolt-Glaser, Glaser and Belury were William Malarkey, Professor Emeritus of Internal Medicine, and Rebecca Andridge, an Assistant Professor of Public Health.

In addition to support from the CCTS and the Clinical and Translational Science Awards (CTSA), the study was funded in part by a grant from the National Center for Complementary and Alternative Medicine, a part of the National Institutes of Health.